Polymeric microspheres for Peptide Synthesis, DNA synthesis, home-care and cosmetics
SpheriSomes® are fatty acid based microspheres which self-assemble in water. These fatty acid microparticles are readily cross-linked amines and polymeric amines including peptides and proteins. When SpheriSomes® formed from fatty acids, such as sebacic acid are cross-linked with an approved food preservative poly-epsilon-lysine using our patented technology the resultant microparticles are antimicrobial. The base component is poly-epsilon-lysine which is well-documented in the scientific literature as an antimicrobial peptide discovered in Japan in the 1980s.
The antibacterial and anti-fungal properties of our unique cross-linked microparticles are well proven and the underlying technology patented by the company in 2012 and is acknowledged in many peer reviewed publications in the scientific literature. A patent covering the SpheriSome® technology specifically for this type of application was granted in 2019.
SpheriSomes® can be further collaboratively engineered or further developed for specific uses, for example, 3D scaffolds, coatings, film, gels, sprays, creams, solutions and suspensions to meet customer specifications. Other amino acid combinations, incorporation of active substances into the multi-laminar layers to further customise to expand the initial formulations to meet the required performance criteria.
SpheriTide® polymeric microspheres for solid phase synthesis consist of poly-ε-lysine cross-linked with multifunctional carboxylic acids. The peptidic nature of the polymer backbone is probably the optimum environment to assemble a peptide by solid phase chemistry ultimately forming a quasi-homogeneous peptide-gel network.
The polymer capacities displayed in the tables in the product options below are a guideline. The precise loading is defined in the data sheet for each batch.
KS is cross-linked with sebacic acid to provide a solid support with excellent solvation and handling properties. In particular this polymer does not have the tendency to stick to the walls of solid phase reactors which is often observed with other hydrophilic solid supports such as polyethylene glycol and polydimethylacrylamide based polymers.
KN is cross-linked with nitrilotriacetic acid to provide a solid support with a tertiary base at the center of each cross-linking function. This has the potential to provide an internal catalyst for amide bond formation but also has the ability to be pre-swollen by conversion to a 1-hydroxybenzotriazole salt which may impart advantages for assembly of difficult peptide sequences.